Genome-wide identification and comparative analysis of coiled-coil proteins

Abstract

Theα-helical coiled-coil is a protein structure
motif well suited for computational prediction. To study the occurrence of
coiled-coil proteins throughout different kingdoms, we have computationally
identified and clustered long coiled-coil proteins from 23 fully-sequenced
genomes. Our results indicate that long coiled-coil proteins occur with
higher frequency in eukaryotes than prokaryotes, with kingdom-specific
families observed in plants and animals. We have established searchable
protein databases containing prediction data for Arabidopsis, rice and Chlamydomonas coiled-coil
proteins to facilitate further studies.